发明名称 |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES |
摘要 |
The present invention relates to a pharmaceutical composition comprising a combination of 1-benzyl-3-hydroxymethyl-indazole derivative, a pressure lowering agent selected from ACE-inhibitors, renin inhibitors, ARBs and CCBs, and/or a cholesterol lowering agent selected from statin derivatives. The combination showed an additive and synergistic activity in reducing MCP-1 levels, thus significantly improving inflammatory response inhibition and consequently reducing complications occurring in patients suffering from inflammatory diseases. |
申请公布号 |
WO2011036047(A1) |
申请公布日期 |
2011.03.31 |
申请号 |
WO2010EP62979 |
申请日期 |
2010.09.03 |
申请人 |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.;GUGLIELMOTTI, ANGELO;GARRONE, BEATRICE;BLE', ALESSANDRO;BIONDI, GIUSEPPE |
发明人 |
GUGLIELMOTTI, ANGELO;GARRONE, BEATRICE;BLE', ALESSANDRO;BIONDI, GIUSEPPE |
分类号 |
A61K31/165;A61K31/30;A61K31/366;A61K31/40;A61K31/415;A61K31/416;A61K31/417;A61K45/06;A61P29/00 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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