发明名称 |
METHODS OF TREATING METABOLIC DISEASE |
摘要 |
It has been discovered that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a co-repressor of the transcription factor Hif1?, a critical regulator of nutrient stress responses. This invention relates generally to methods of reducing expression or activity of SIRT6 to reduce or inhibit hyperglycemia or obesity in a subject. |
申请公布号 |
WO2011038110(A2) |
申请公布日期 |
2011.03.31 |
申请号 |
WO2010US49986 |
申请日期 |
2010.09.23 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;MOSTOSLAVSKY, RAUL |
发明人 |
MOSTOSLAVSKY, RAUL |
分类号 |
A61K39/395;A61P3/04;A61P3/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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