| 摘要 |
The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection. |
| 申请人 |
HANWHA CHEMICAL CORPORATION;LEE, JUNGTAE;MOON, KYUNGDUK;YOON, JIYONG;SUNG, BYUNGJE;LEE, DONGHEON;LEE, ILSUN;LEE, DONGEUN;RYU, SUYEON;PARK, YOUNGWOO;CHOI, SO-YOUNG;PARK, JIHYUN;JANG, MYEOUNGHEE |
发明人 |
LEE, JUNGTAE;MOON, KYUNGDUK;YOON, JIYONG;SUNG, BYUNGJE;LEE, DONGHEON;LEE, ILSUN;LEE, DONGEUN;RYU, SUYEON;PARK, YOUNGWOO;CHOI, SO-YOUNG;PARK, JIHYUN;JANG, MYEOUNGHEE |
