发明名称 ANTAGONISTS OF DSG2 FOR TREATMENT OF CANCER
摘要 The present invention relates to agents for use in treating cancer. The agent to be used is an antagonist of Dsg2, wherein said antagonist modulates the function of the amino acid sequence: TQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYR (SEQ ID NO:1), or a fragment or variant thereof, of the EC2 domain of Dsg2. Also included in the invention are specific polypeptides and pharmaceutical preparations. Also included in the invention is a method of screening for antagonists of Dsg2, wherein said antagonist modulates the function of the amino acid sequence: TQDVFVGS VEELSAAHTLVMKINATDADEPNTLNSKISYR (SEQ ID NO: 1), or a fragment or variant thereof, of the EC2 domain of Dsg2.
申请公布号 CA2774836(A1) 申请公布日期 2011.03.31
申请号 CA20102774836 申请日期 2010.09.22
申请人 ASCLEPIUMM LIMITED 发明人 CHEN, MIN-CHE
分类号 C07K16/28;A61K38/17;A61P35/00;C07K14/705;G01N33/50;G01N33/68 主分类号 C07K16/28
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