发明名称 |
Polynucleotide therapy |
摘要 |
The invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector. The invention also provides a composition comprising a polynucleotide encoding one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present non-physiologically in a treated animal useful in treating or preventing a disease associated with the self-protein(s), - polypeptide(s), or -peptide(s) present in and/or the target of a non-physiologic process in the animal.
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申请公布号 |
EP2301552(A1) |
申请公布日期 |
2011.03.30 |
申请号 |
EP20100178426 |
申请日期 |
2002.11.21 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
FONTOURA, PAULO;GARREN, HIDEKI;ROBINSON, WILLIAM, H.;STEINMAN, LAWRENCE;RUIZ, PEDRO JOSE;UTZ, PAUL J. |
分类号 |
A61K31/70;C12N15/09;A61K38/20;A61K39/00;A61K48/00;A61P1/16;A61P3/04;A61P3/10;A61P5/48;A61P19/00;A61P19/02;A61P25/00;A61P25/16;A61P25/28;A61P29/00;A61P37/00 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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