Use of allogeneic cell lines to load antigen-presenting cells to elicit or eliminate immune responses

摘要

The invention relates to cytotoxic T cells and their use in mounting an immune response. The T cells are produced by culturing naïve T cells with antigen-presenting cells, including dendritic cells, that are loaded with antigens from dead or dying cells or cell portions, including allogeneic cell lines, to which the immune response is desired. The invention further relates to the use of T cells in elimination of undesired immune responses such as graft versus host disease or host versus graft rejection.