发明名称 |
Particulate composition containing anhydrous crystalline 2-O-alpha -D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof |
摘要 |
The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O- ± -D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O- ± -D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O- ± -D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25°C under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof. |
申请公布号 |
EP2301944(A1) |
申请公布日期 |
2011.03.30 |
申请号 |
EP20100175307 |
申请日期 |
2010.09.03 |
申请人 |
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO |
发明人 |
SHIBUYA, TAKASHI;IZAWA, SEISUKE;NISHIMOTO, TOMOYUKI;FUKUDA, SHIGEHARU;MIYAKE, TOSHIO |
分类号 |
C07H17/04;C12P19/60 |
主分类号 |
C07H17/04 |
代理机构 |
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代理人 |
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主权项 |
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