Methods for prognosticating progression or long term non-progression of a HIV infection or HIV-associated disorders in a patient

摘要

The present invention relates to a method for analyzing the Vpr protein of a HIV, which method comprises: in a biological sample previously obtained from a patient infected with a HIV, and in particular with a HIV-1, performing an analysis of the nucleotide sequence encoding the tested Vpr protein and/or of the amino acid sequence of the tested Vpr protein, in order to determine the amino acid residue of its sequence which would correspond to the residue at position 84 in the sequence of a reference HIV Vpr protein and/or the amino acid residue of its sequence which would correspond to the residue at position 85 in the sequence of a reference HIV Vpr protein (for example the Vpr protein of the 89.6 HIV-1 isolate). This method is in particular useful for functionally classifying one or several HIV isolate(s), or for prognosticating, in a patient, progression or long-term non-progression of a HIV infection or of HIV-associated disorders.