| 摘要 |
1300998 Effervescent antibiotic compositions BIOCHEMIE GmbH 13 April 1970 [2 May 1969] 17419/70 Heading A5B Effervescent compositions comprise a carbonate or bicarbonate of particle size 50 to 500Ám, an organic acid (e.g. citric or tartaric) of particle size 200 to 1000 Ám and an antibiotic. The weight ratio of carbonate or bicarbonate to acid is in the range 1:1 to 2.0:0.5, that of antibiotic to effervescent couple being from 1:5.5 to 1:15. Specified antibiotics are the sodium and potassium salts of ampicillin, cloxacillin, oxacillin, phenethicillin, phenoxymethyl penicillin, propicillin, novobiocin, fusidinic acid, chloramphenical leucine carbamate and colistin methane sulphonate. The compositions are stated to dissolve with effervescence to give clear, stable solutions, the pH being maintained within the range in which the antibiotic is stable. |
