发明名称 |
Enzymatic conversion of blood group B, and AB red blood cells using an alpha-galactosidase with unique substrate specificities and kinetic properties |
摘要 |
There is disclosed a strain of prokaryotic cell capable of expressing an ±-galactosidase for removing type B antigens from blood group B or AB reactive cells in blood products, wherein said ±-galactosidase has the following characteristics: (i) no less than 10% activity with blood group B oligosaccharides compared to simple ±-Gal monosaccharide derivatives, and (ii) active in red blood cell conversion of blood group B oligosaccharides at neutral pH. |
申请公布号 |
EP2302045(A1) |
申请公布日期 |
2011.03.30 |
申请号 |
EP20100182388 |
申请日期 |
2002.09.25 |
申请人 |
VELICO MEDICAL, INC. |
发明人 |
CLAUSEN, HENRIK;DE LA VEGA, HUMBERTO;HILL, CHERYL;LIU, QIYONG, PETER |
分类号 |
C12N9/24;A61K35/18;A61P7/06;C12N1/20;C12N1/21;C12N5/078;C12N9/40;C12P19/24;C12Q1/34 |
主分类号 |
C12N9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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