发明名称 |
ANTI-AMYLOID IMMUNOGENIC COMPOSITIONS, METHODS AND USES |
摘要 |
The present invention provide a recombinant polypeptide based on a tandem array of repeats of the N-terminal 7 amino acids of A²42, preferably positioned within the active loop site of a carrier such as bacterial thioredoxin (Trx). Antibodies raised against these recombinant constructs were found to have a very strong affinity for A²42, opening up possibilities for diagnosis and treatment of Alzheimer's disease. |
申请公布号 |
EP2300494(A1) |
申请公布日期 |
2011.03.30 |
申请号 |
EP20090797424 |
申请日期 |
2009.07.07 |
申请人 |
CHIESI FARMACEUTICI S.P.A. |
发明人 |
IMBIMBO, BRUNO, PIETRO;OTTONELLO, SIMONE;VILLETTI, GINO;MORETTO, NADIA |
分类号 |
C07K14/47;A61K38/04;A61K38/10;A61K38/17;A61K39/00;A61K39/395;C07K7/08 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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