发明名称 |
Use of proteasome inhibitors for the treatment of viral infections |
摘要 |
<p>Composition for treating viral infections contains, as active component, at least one proteosome inhibitor (I). ACTIVITY : Virucide; cytostatic; hepatotropic; anti-HIV; nootropic; nephrotropic. MECHANISM OF ACTION : (I) inhibit, regulate or otherwise affect activity of the ubiquitin-proteosome pathway, especially the enzymatic activity of the complete 26S proteosome complex or the free (i.e. not assembled with regulatory subunits) 20S catalytically active proteosome structure. Particularly they (ir)reversibly block the proteolytic (trypsin, chymotrypsin or postlutamyl-peptide hydrolase) activities of the proteosome, so inhibit maturation, release and replication of viruses. Particularly they inhibit release of hepatitis virions or, for retroviruses, prevent processing of the gag protein by viral proteases. (I) may also modulate expression or activity of the p53 tumor suppressor and alter phosphorylation of herpes viral nucleocapsids.</p> |
申请公布号 |
EP2301565(A1) |
申请公布日期 |
2011.03.30 |
申请号 |
EP20100182351 |
申请日期 |
2001.10.11 |
申请人 |
VIROLOGIK GMBH |
发明人 |
SCHUBERT, ULRICH;WILL, HANS;TESSMER, UWE;SIRMA, HUESEYIN;PRASSALOW, ALEXIJ;SCHUBERT, EVELYN;HOHENBERG, HEINZ;WELKER, REINHOLD |
分类号 |
A61K38/58;C07D491/044;A61K9/48;A61K31/00;A61K31/166;A61K31/336;A61K31/365;A61K31/4015;A61K31/407;A61K31/415;A61K31/47;A61K31/5375;A61K31/704;A61K38/00;A61K38/04;A61K38/05;A61K38/06;A61K38/07;A61K38/55;A61K45/00;A61K45/06;A61K48/00;A61P1/16;A61P25/28;A61P31/12;A61P31/14;A61P31/18;A61P31/20;A61P35/00;A61P35/02;A61P43/00;C07H15/252 |
主分类号 |
A61K38/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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