| 发明名称 |
SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF |
| 摘要 |
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by general Formula (I), wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the discovery that com-pounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which un-controlled growth and spread of abnormal cells occurs.
|
| 申请公布号 |
CA2390164(C) |
申请公布日期 |
2011.03.29 |
| 申请号 |
CA20002390164 |
申请日期 |
2000.11.03 |
| 申请人 |
CYTOVIA, INC. |
发明人 |
DREWE, JOHN A.;CAI, SUI XIONG;WANG, YAN |
| 分类号 |
C07D311/58;C07D491/052;A61K31/352;A61K31/353;A61K31/36;A61K31/381;A61K31/407;A61K31/4162;A61K31/4178;A61K31/4433;A61K31/4709;A61K47/10;A61K47/14;A61K47/22;A61K47/24;A61K47/26;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/40;A61K47/42;A61K47/44;A61P1/04;A61P17/02;A61P17/06;A61P29/00;A61P35/00;A61P37/06;A61P43/00;C07D295/04;C07D311/92;C07D405/04;C07D407/04;C07D409/04;C07D491/04;C07D491/147;C07D493/04 |
主分类号 |
C07D311/58 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
