发明名称 |
Stabiliser for radiopharmaceuticals |
摘要 |
A stabilized radiopharmaceutical composition, a kit including same, and a method for making same, where the radiopharmaceutical is (i) susceptible to either reductive degradation or radiolysis and which includes a metal complex of a radionuclide with a ligand, (ii) a first stabilizer for the radiopharmaceutical which is an amino-substituted aromatic carboxylic acid or a salt, ester or amide thereof, and (iii) a second stabilizer for the radiopharmaceutical which is a diphosphonic acid or salt thereof. The first and second stabilizers are present in an amount effective to stabilize the radiopharmaceutical, and the radiopharmaceutical is not a metal complex of the diphosphonic acid. |
申请公布号 |
US7914768(B2) |
申请公布日期 |
2011.03.29 |
申请号 |
US20040296952 |
申请日期 |
2004.10.21 |
申请人 |
GE HEALTHCARE LIMITED;NIHON MEDI-PHYSICS, CO., LTD. |
发明人 |
STOREY ANTHONY E.;BRAUERS GEORG;HANAOKA KOICHI;MINOSAKO YOSHIHITO;HOMMA KOICHI;SHIRAKAMI YOSHIFUMI |
分类号 |
A61K47/02;A61K51/00;A61K47/16;A61K47/18;A61K47/22;A61K47/24;A61K51/04;A61M36/14;A61P43/00 |
主分类号 |
A61K47/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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