| 摘要 |
A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein Rrepresents a group such as an alkyl group; X, X, Xand Xrepresent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carryingС introduced thereinto or a radioactive halogen atom, provided that at least one of X, X, Xand Xrepresents an alkoxy group carryingС introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained. |
