IMPROVEMENT OF TENDON REPAIR

摘要

The invention provides the use of mannose-6-phosphate (M6P) in the manufacture of a medicament for the improvement of tendon repair after injury, wherein the medicament comprises M6P at a concentration of at least 500mM. The medicaments of the invention may be useful in decreasing tendon adhesion formation after injury, and additionally or alternatively, in improving the quality of replacement tendon formed after injury. The medicaments may preferably be for administration by injection. The medicaments may be useful in improving tendon repair after an injury selected from the group consisting of : sharp trauma injury; blunt trauma injury; traction injury; torsion injury; crush injury; lacerations; ruptures; bicep tendon rupture; penetrating injuries; surgical injuries; sports injuries, such as mallet injury; and degenerative conditions, such as trigger thumb or repetitive strain injury.