发明名称 |
COMPOSITIONS AND METHODS FOR IDENTIFICATION OF PARP FUNCTION, INHIBITORS, AND ACTIVATORS |
摘要 |
The invention provides nucleic acids encoding PARP fusion proteins, PARP fusion proteins, antibodies that bind to one or more of these PARP fusion proteins, and transgenic cells expressing one or more PARP fusion proteins. The invention also provides methods for identifying an agent as a specific PARP inhibitor or activator requiring contacting one or more PARP fusion proteins with a labeled nicotinamide adenine dinucleotide substrate and the agent and measuring the amount of labeled of ADP-ribose covalently attached to the one or more PARP fusion proteins. The invention also provides methods for identifying an agent that specifically binds to one or more PARP fusion proteins and methods for quantitating the level of one or more PARP proteins in a sample. |
申请公布号 |
WO2010151656(A3) |
申请公布日期 |
2011.03.24 |
申请号 |
WO2010US39802 |
申请日期 |
2010.06.24 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CHANG, PAUL;VYAS, SEJAL |
发明人 |
CHANG, PAUL;VYAS, SEJAL |
分类号 |
C07H21/04;C12N9/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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