MEASUREMENT OF PROTEIN KINASE ACTIVITY IN CEREBROSPINAL FLUID FOR DIAGNOSIS OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

摘要

The present invention relates to the use of endogenous protein kinase activity in cerebrospinal fluid for the classification, diagnosis and prognosis of neurological and psychiatric disorders as well as for predicting and monitoring treatment effects. An array of substrates for protein kinases, immobilized on a porous matrix, is used to monitor the protein kinase activity in cerebrospinal fluid. The method of the present invention enables the early diagnosis and discrimination between neurodegenerative disorders.