SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME
摘要
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
申请公布号
CA2774374(A1)
申请公布日期
2011.03.24
申请号
CA20102774374
申请日期
2010.09.17
申请人
VANDERBILT UNIVERSITY
发明人
CONN, P. JEFFREY;LINDSLEY, CRAIG W.;EMMITTE, KYLE A.;WEAVER, CHARLES DAVID;RODRIGUEZ, ALICE L.;FELTS, ANDREW S.;JONES, CARRIE K.;BATES, BRITTNEY S.