| 发明名称 |
PROTEIN KINASE CONJUGATES AND INHIBITORS |
| 摘要 |
<p>The invention relates to protein conjugates that contain a protein kinase containgn a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.</p> |
| 申请公布号 |
CA2773985(A1) |
申请公布日期 |
2011.03.24 |
| 申请号 |
CA20102773985 |
申请日期 |
2010.09.15 |
| 申请人 |
AVILA THERAPEUTICS, INC. |
发明人 |
SINGH, JUSWINDER;PETTER, RUSSELL COLYN;NIU, DEQIANG;QIAO, LIXIN;KLUGE, ARTHUR;LOBB, ROY;GHOSH, SHOMIR;ZHU, ZHENDONG |
| 分类号 |
A61K31/519;A61K31/395;A61K31/4245;A61K31/4365;A61K31/44;A61K31/444;A61K31/5025;A61K31/506;A61K31/5377;A61K31/5383;C07D213/81;C07D239/48;C07D401/12;C07D403/12;C07D417/12;C07D417/14;C07D471/10;C12N9/12 |
主分类号 |
A61K31/519 |
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