摘要 |
<p>Disclosed is a novel porphyrin metal complex which is safe in vivo and satisfies requirements for relaxation ability, cancer cell selectivity, organ selectivity and the like. The porphyrin metal complex is able to be applied to an MRI contrast medium. Also disclosed is a molecular aggregate of the porphyrin metal complex. Specifically disclosed is a porphyrin metal complex represented by formula (1). (In the formula, R1-R12 each represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, a sulfonyl group, a hydroxy group, an amino group, a carboxyl group, an optionally substituted alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, an optionally substituted phenyl group, or a group selected from the group consisting of oligoethylene glycol methyl ether groups represented by formula (2) (wherein n represents a number of 1-10), (provided that at least one of the R1-R12 represents a group represented by formula (2)); and M represents a divalent metal atom or a trivalent to pentavalent metal atom which may have a substituent atom or a substituent group.)</p> |
申请人 |
KYUSHU UNIVERSITY;NISSAN CHEMICAL INDUSTRIES, LTD.;KOGA, NOBORU;KARASAWA, SATORU;HAYASHI, HIROYUKI;OKUBO, KENGO |
发明人 |
KOGA, NOBORU;KARASAWA, SATORU;HAYASHI, HIROYUKI;OKUBO, KENGO |