发明名称 |
PROCESS FOR PRODUCING CRYSTALLINE NUCLEUS AND METHOD OF SCREENING CRYSTALLIZATION CONDITIONS |
摘要 |
The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW. <IMAGE> |
申请公布号 |
EP1559814(B8) |
申请公布日期 |
2011.03.23 |
申请号 |
EP20030792820 |
申请日期 |
2003.08.25 |
申请人 |
SOSHO, INC. |
发明人 |
SASAKI, TAKATOMO;MORI, YUSUKE;YOSHIMURA, MASASHI;ADACHI, HIROAKI;MASUHARA, HIROSHI;HOSOKAWA, YOUICHIROH;TAKANO, KAZUFUMI |
分类号 |
C30B7/02;B01D9/02;C30B7/00;C30B29/58 |
主分类号 |
C30B7/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|