The present invention is directed to a synthetic nucleic acid sequence which encodes an alpha-galactosidase wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.
申请公布号
EP2275559(A3)
申请公布日期
2011.03.23
申请号
EP20100180592
申请日期
2001.10.11
申请人
SHIRE HUMAN GENETIC THERAPIES, INC.
发明人
SELDEN, RICHARD F.;MILLER, ALLAN M.;TRECO, DOUGLAS A.
