发明名称 |
Carboline derivatives useful in the treatment of cancer |
摘要 |
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
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申请公布号 |
EP2298304(A2) |
申请公布日期 |
2011.03.23 |
申请号 |
EP20110150082 |
申请日期 |
2006.04.17 |
申请人 |
PTC THERAPEUTICS, INC. |
发明人 |
MOON, YOUNG-CHOUN;CAO, LIANGXIAN;ARASU, TAMIL;QI, HONGYAN;CHOI, SOONGYU;LENNOX, WILLIAM JOSEPH;CORSON, DONALD THOMAS;HWANG, SEONGWOO;DAVIS, THOMAS |
分类号 |
A61K31/497;A61K31/337;A61K31/437;A61K31/444;A61K31/4745;A61K31/506;A61K31/513;A61K31/5377;A61K31/541;A61K31/5513;A61K31/724;A61K39/395;A61P35/00;G01N33/574 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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