DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION

摘要

The present invention relates to compounds of formula (I) below in which:—R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms,—R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms,—A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle,—X represents a nitrogen atom or a CH group, and—Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and—Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a—CN,—SO2NR12R13,—SO2R9,—COOR15 or—COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.