发明名称 |
Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors |
摘要 |
The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-&kgr;B, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
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申请公布号 |
US7910523(B2) |
申请公布日期 |
2011.03.22 |
申请号 |
US20040851864 |
申请日期 |
2004.05.20 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GORENSTEIN DAVID G.;LUXON BRUCE A.;LEARY JAMES |
分类号 |
C40B50/16;A61K;C12N15/10;G01N33/53;G01N33/558;G01N33/68 |
主分类号 |
C40B50/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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