ALCOOLS ALPHA-(AMINOALKYL)-3,4-DIHYDROXYBENZYLIQUES HALOGENES

摘要

Halogen substituted alpha -(aminoalkyl)-3,4-dihydroxybenzyl alcohols having beta -adrenergic stimulant activity, particularly as selective bronchodilators. The alpha -aminomethyl derivatives are prepared by the condensation of an appropriately substituted styrene oxide with a primary amine followed by removal of the ether protective group(s). The alpha -aminoethyl or alpha -aminopropyl derivatives are prepared by the condensation of an appropriately substituted alpha -bromoalkyl phenyl ketone with an N-benzyl secondary amine followed by reduction of the ketone moiety and removal of the ether protective group(s).