发明名称 |
Common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1) and uses thereof |
摘要 |
A novel protein Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 (CLEVER-1) is described. CLEVER-1 mediates leukocyte and malignant cell binding to vascular and lymphoid endothelial cells. CLEVER-1 is the first protein that has been reported to mediate both influx into and efflux from the lymph nodes. Also provided are methods of treating inflammation and preventing metastasis of malignant cells by providing an inhibitor of CLEVER-1 binding.
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申请公布号 |
US7910097(B2) |
申请公布日期 |
2011.03.22 |
申请号 |
US20080073451 |
申请日期 |
2008.03.05 |
申请人 |
FARON PHARMACEUTICALS OY |
发明人 |
JALKANEN SIRPA;IRJALA HEIKKI;SALMI MARKO |
分类号 |
A61K39/395;G01N33/50;A61K45/00;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07K14/705;C07K16/28;C12N15/02;C12P21/08;C12Q1/02;G01N33/15;G01N33/53;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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