发明名称 |
Human p53 splice variant displaying differential transcriptional activity |
摘要 |
Novel human p53 splice variant displaying differential transcriptional activity Described is a nucleic acid molecule encoding a p53 variant characterized in that it is capable of transactivating the p21- and 14-3-3&sgr;-promoter but not the mdm2-, bax- and PIG3-promoter. Preferably, in said p53 variant exon 7, exon 8 and/or exon 9 are partially or entirely deleted. Finally, means for inhibiting the activity of this p53 variant are described which are useful for the therapy of cancer.
|
申请公布号 |
US7910704(B2) |
申请公布日期 |
2011.03.22 |
申请号 |
US20050236014 |
申请日期 |
2005.09.27 |
申请人 |
DEPPERT WOLFGANG W;DORNREITER IRENE |
发明人 |
DEPPERT WOLFGANG W.;DORNREITER IRENE |
分类号 |
C07K14/00;A61K38/16;A61K39/00;A61K48/00;C07K14/47;C07K16/00;C07K16/18;C07K17/00;C12N15/11;C12N15/12;C12P21/08;C12Q1/68 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|