发明名称 |
COMBINATION OF (A) A PHOSPHOINOSITIDE 3-KINASE INHIBITOR AND (B) A MODULATOR OF RAS/RAF/MEK PATHWAY |
摘要 |
<p>The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the Ras/Raf/Mek pathway for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.</p> |
申请公布号 |
KR20110028651(A) |
申请公布日期 |
2011.03.21 |
申请号 |
KR20117003118 |
申请日期 |
2009.07.10 |
申请人 |
NOVARTIS AG |
发明人 |
GARCIA ECHEVERRIA CARLOS;MAIRA SAUVEUR MICHEL;STUART DARRIN;WEE SUSAN;FRITSCH CHRISTINE;NAGEL TOBI |
分类号 |
A61K31/4188;A61K45/06;A61P35/00;C07D487/04 |
主分类号 |
A61K31/4188 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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