| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to a compound of formula IV: , where: R1 represents Cl or F; R3 represents H, Me, Et, OH, MeO-, EtO-, HOCH2CH2O-, HOCH2C(Me)2O-, (S)-MeCH(OH)CH2O-, (R)-HOCH2CH(OH)CH2O-, cyclopropyl-CH2O-, HOCH2CH2-, , , , , or , R7 represents methyl or ethyl which are optionally substituted with one or more F; R8 represents Br, I or SMe; and R9 represents H, C1-C4alkyl, Cl or CN where said alkyl it optionally substituted with one or more groups independently chosen from F or CN provided when a) R1 represents F, R8 represents Br, R9 represents H, and R7 represents either Me, or Et, then R3 cannot represent HOCH2CH2O; b) R1 represents F, R8 represents I, R9 represents H, and R3 represents MeO then R7 cannot represent Me; c) R1 represents F, R8 represents Me, R9 represents H, and R3 represents HOCH2CH2O then R7 cannot represent Me; and d) R1 represents F, R8 represents Br, R9 represents H, and R3 represents cyclopropyl-CH2O then R7 cannot represent Me, as well as to the use of said compound in preparing a drug for treating hyperproliferative disorder or an inflammatory state and to a pharmaceutical composition which inhibits MEK. ^ EFFECT: there are prepared and described new compounds effective in treating hyperproliferative diseases, such as cancer and inflammation. ^ 17 cl, 25 ex, 8 tbl, 15 dwg |
