1-ALKYL-2-ALKYLCARBAMOYL-GLYCERINS EXHIBITING ANTIHYPERTENSIVE ACTIVITY, AND METHOD FOR PREPARING THEREOF

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine, namely to an agent exhibiting antihypertensive activity which represents 1-alkyl-2-alkylcarbamoylglycerins of general formula I . In formula I R means hydrocarbon radical -(CH2)nCH3 (n=10-18), R1 means methyl or ethyl. Also, the invention refers to a method for preparing the compounds of formula I. The method consists in the fact that parent 1-alkylglycerins of general formula II react with trimethylchlorosilane with using triethylamine in toluene medium at temperature -20C to 0C, then the reaction mass is added with appropriate alkylisocyanate and processed with ammonium bifluoride in methanol medium at room temperature. ^ EFFECT: preparation of the agent exhibiting antihypertensive activity. ^ 2 cl, 7 ex