NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING NUCLEIC ACIDS
摘要
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.
申请公布号
WO2011032034(A2)
申请公布日期
2011.03.17
申请号
WO2010US48520
申请日期
2010.09.10
申请人
UNIVERSITY OF IDAHO;HRDLICKA, PATRICK, J.;KUMAR, PAWAN;OESTERGAARD, MICHAEL, E.
发明人
HRDLICKA, PATRICK, J.;KUMAR, PAWAN;OESTERGAARD, MICHAEL, E.