发明名称 |
NEUE N-ACETYLGLUCOSAMIN TRANSFERASE, CODIERENDE NUKLEINSÄUREN, SPEZIFISCHE ANTIKÖRPER, SOWIE VERWENDUNG ZUR KREBSDIAGNOSE |
摘要 |
<p>Described are an enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through a beta 1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through the beta 1,3-linkage was cloned from human colon and stomach cells, and the gene was sequenced. The enzyme was expressed, and a monoclonal antibody to the enzyme was prepared. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.</p> |
申请公布号 |
DE60239103(D1) |
申请公布日期 |
2011.03.17 |
申请号 |
DE2002639103 |
申请日期 |
2002.10.16 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY |
发明人 |
NARIMATSU, HISASHI;INABA, NIRO;IWAI, TOSHIE |
分类号 |
C12N15/54;C07K14/47;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/10;C12Q1/68;G01N33/53;G01N33/574 |
主分类号 |
C12N15/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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