发明名称 |
MUTANT SODIUM CHANNEL NAV1.7 AND METHODS RELATED THERETO |
摘要 |
Described are mutant Navl.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1.7 sodium channel alpha-subunit, methods for determining a Nav1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with a sodium channel mutation, and methods of identifying a compound that modulates mutant Nav1.7 sodium channels. Other materials, compositions, articles, devices, and methods relating to mutant Nav1.7 sodium channels are also described herein. |
申请公布号 |
WO2011032112(A2) |
申请公布日期 |
2011.03.17 |
申请号 |
WO2010US48680 |
申请日期 |
2010.09.13 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;LEPPERT, MARK, F.;SINGH, NANDA, A. |
发明人 |
LEPPERT, MARK, F.;SINGH, NANDA, A. |
分类号 |
C12Q1/68;C12N15/12;C12N15/85 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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