| 摘要 |
Disclosed is a formulation for use in the exfoliation of a mammalian subject, the formulation comprising: (i) one or more active agents selected from the group, (a), consisting of: a bacterial exfoliative toxin, or active derivative, analogue or truncated portion thereof; and/or (ii) one or more active agents selected from the group, (b), consisting of: a binding partner which binds to desmoglein 1, desmoglein 2, desmoglein 3 or desmoglein 4; and/or (iii) one or more active agents selected from the group, (c), consisting of: a binding partner which binds to laminin 5, laminin 6, integrin beta 4 subunit, collagen VII, collagen XVII, or Bullous Pemphigoid antigen 230 proteins; said active agent(s) being present in the formulation at a known concentration sufficient such that the formulation causes appropriate exfoliation of the subject's skin within a contact time in the range of 2 minutes to 1 hour; (iv) a cosmetically acceptable carrier, diluent or excipient. |
