<p>The present invention relates to a form of crystalline 4'-epidaunorubicin hydrochloride which is stable and readily soluble, and to a process for the production thereof. This process comprises crystallizing 4'-epidaunorubicin hydrochloride in a solvent system including (a) solvent A which is selected from the group consisting of Cl and C2 halogenated solvents and mixtures thereof, (b) solvent B which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, and (c) solvent C which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4'-epidaunorubicin hydrochloride than solvent B.</p>
申请公布号
WO2011029576(A1)
申请公布日期
2011.03.17
申请号
WO2010EP05498
申请日期
2010.09.08
申请人
W. C. HERAEUS GMBH;KUNNARI, TERO;BINDERNAGEL, HOLGER;WEISER, SASCHA;LUPTON, ANDREW;WALLERT, STEFAN
发明人
KUNNARI, TERO;BINDERNAGEL, HOLGER;WEISER, SASCHA;LUPTON, ANDREW;WALLERT, STEFAN