INTERMITTENT AND PULSE LITHIUM TREATMENTS FOR SCAR REVISION AND WOUND HEALING

摘要

The invention relates to intermittent lithium treatments, or a single pulse lithium treatment for scar revision and wound healing in human subjects. Uses of compositions containing compounds that liberate lithium ions are described, including adjuvants and devices for administration. The intermittent treatment protocol involves multiple courses of lithium treatment interrupted by lithium treatment "holidays". For the single pulse protocol, a dose of lithium is administered over a short period of time. The lithium treatment(s) can be used in combination with other treatments for scar revision, wound healing, and hair follicle neogenesis. Such combination treatments may involve mechanical or physical treatments that modulate scar revision or wound healing, or that cause integumental perturbation, and/or chemical treatments that modulate wound healing, scar revision, or hair follicle neogenesis or that cause integumental perturbation or immune stimulation for the treatment of wounds or revision of scars.