发明名称 |
MODULATING ANGIOGENESIS |
摘要 |
<p>Hemangioblasts in adult bone marrow participate in new blood vessel formation. By modulating the differentiation of hemangioblasts into blood vessel cells, angiogenesis in a particular tissue can be increased or decreased. The present invention features compositions and methods for reducing tumor vasculogenesis, treating leukemia, and/or treating or preventing leukemia relapse. In particular, the invention provides an SDF-1 binding agent (e.g., antibody, antisense, ribozyme) for the treatment or prevention of a neoplasia, such as leukemia. Intravitreal injection of antibodies that block SDF-1 activity inhibited induced retinal neovascularization mediated by hemangioblasts. Anti-SDF-1 ribozymes and SDF-1 anti-sense RNA expression constructs significantly reduced migration of cells that create new vessels in the eye.</p> |
申请公布号 |
WO2010085588(A8) |
申请公布日期 |
2011.03.17 |
申请号 |
WO2010US21704 |
申请日期 |
2010.01.22 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;SCOTT, EDWARD, W.;COGLE, CHRISTOPHER, R. |
发明人 |
SCOTT, EDWARD, W.;COGLE, CHRISTOPHER, R. |
分类号 |
A61K39/395;A61K38/16;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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