A METHOD FOR MANUFACTURING 4-(5-METHYLPYRIDIN-2-YLAMINO)PIPERIDINE-1-CARBOXYLIC ACID DERIVATIVE

摘要

In order to establish a novel process for the production of 5-methyl-2-(piperidin-4-ylamino)pyridine, a useful process for the industrial production of 4-(5-methylpyridin-2-ylamino)piperidine-1-carboxylic acid derivatives has been established, said useful process being represented by the reaction formula [wherein R is C1-6 straight-chain or branched alkyl or C7-12 aralkyl]. The useful process comprises conducting the reaction represented by the reaction formula in a reaction fluid that contains an aromatic monocyclic hydrocarbon as a reaction medium either in the presence of a reducing agent consisting of sodium triacetoxyborohydride or after beforehand adding sodium borohydride and acetic acid to the reaction fluid.