BROAD-SPECTRUM SUBSTITUTED BENZISOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a medical agent which is active against a wild-type HIV virus and exhibits the activity of a broad-spectrum against diversified variant HIV virus exhibiting resistance properties against a well-known protease inhibitor. SOLUTION: This invention relates to a benzisoxazole sulfonamide derivative represented by formula (I), wherein R1is cycloalkyl, heterocycle, or the like; R2is hydrogen, alkyl, or the like; R3is alkyl, cycloalkyl, or the like; R4is cycloalkyl, alkenyl, or the like; R12is -NH2, or the like; and L is -C(=O)-, or the like. COPYRIGHT: (C)2011,JPO&INPIT