METHODS OF PREPARATION OF MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS

摘要

The present application describes novel intermediates useful in the synthesis of mAChRs and methods for preparing these intermediates, comprising a compound of Formula (II): wherein, P is a suitably nitrogen protecting group; R is selected from the group consisting of C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C3-6cycloalkyl, C3-6cycloalkenyl, heterocyclic, heterocyclic C1-4alkyl, aryl, aryl C1-4alkyl and heteroaryl C1-4alkyl; and Y is a suitable leaving group.