发明名称 |
Method for Opening Tight Junctions |
摘要 |
The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.
|
申请公布号 |
US2011064792(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20080682331 |
申请日期 |
2008.10.13 |
申请人 |
HUMPHRIES PETER;CAMPBELL MATTHEW;KING ANNA-SOPHIA |
发明人 |
HUMPHRIES PETER;CAMPBELL MATTHEW;KING ANNA-SOPHIA |
分类号 |
A61K31/7088;A61K9/127;A61K38/00;A61K38/43;A61P25/00;A61P25/28;A61P27/02;A61P35/00;C12N5/071;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|