发明名称 |
Attenuated Live Triple G Protein Recombinant Rabies Virus Vaccine for Pre- and Post-Exposure Prophylaxis of Rabies |
摘要 |
The invention provides a recombinant rabies viruses comprising three copies of a mutated G gene wherein each G gene encodes a rabies virus glycoprotein having the amino acid 194 mutated to a serine and the amino acid 333 is mutated to a glutamic acid. The recombinant rabies virus is nonpathogenic in immunodeficient mammals and can be used in a vaccine to induce an immune response protect mammals from infection by rabies virus as well as clear a pre-existing rabies virus infection from neural tissues.
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申请公布号 |
US2011064764(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20100879335 |
申请日期 |
2010.09.10 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
FABER MILOSZ;DIETZSCHOLD BERNHARD;HOOPER DOUGLAS CRAIG |
分类号 |
A61K39/205;A61K35/76;A61P31/14;A61P37/04;C12N7/04 |
主分类号 |
A61K39/205 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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