发明名称 |
METHOD OF PRODUCING BICYCLO[3.1.0] HEXANE DERIVATIVE USING ENZYME |
摘要 |
Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.
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申请公布号 |
US2011065934(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20100950609 |
申请日期 |
2010.11.19 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD. |
发明人 |
HIROTSUKA MITSUAKI;SASAKI JOJI;KAMIYAMA HIROAKI;OSHIDA MOTOKO;ISHII TAKAAKI |
分类号 |
C07C67/00;C07C67/26;C07D317/72;C12P7/62;C12P17/04 |
主分类号 |
C07C67/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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