发明名称 |
CONTROLLED PLATELET ACTIVATION TO MONITOR THERAPY OF ADP ANTAGONISTS |
摘要 |
A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within a range suitable for platelet aggregation; 3) a platelet GPIIb/IIIa receptor ligand immobilized on a solid surface; 4) one or more agents to enhance a signal transduction pathway and 5) a receptor activator. The combination is incubated under conditions for agglutinating particles. Platelet-mediated agglutination is assessed in the agitated mixture. The absence of agglutination indicates that the individual has a reduced ability to form platelet thrombi.
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申请公布号 |
US2011065125(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
US20100876730 |
申请日期 |
2010.09.07 |
申请人 |
ACCUMETRICS, INC. |
发明人 |
COLLER BARRY S.;DURBIN DENNIS |
分类号 |
G01N33/53;A61K31/557;A61K39/395;A61K49/00;C12Q;C12Q1/00;G01N33/567;G01N33/86 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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