发明名称 |
CRYSTALLIZATION OF 4'-EPIDAUNORUBICIN X HCI |
摘要 |
The present invention relates to a form of crystalline 4'-epidaunorubicin hydrochloride which is stable and readily soluble, and to a process for the production thereof. This process comprises crystallizing 4'-epidaunorubicin hydrochloride in a solvent system including (a) solvent A which is selected from the group consisting of Cl and C2 halogenated solvents and mixtures thereof, (b) solvent B which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, and (c) solvent C which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4'-epidaunorubicin hydrochloride than solvent B. |
申请公布号 |
CA2772260(A1) |
申请公布日期 |
2011.03.17 |
申请号 |
CA20102772260 |
申请日期 |
2010.09.08 |
申请人 |
HERAEUS PRECIOUS METALS GMBH & CO. KG |
发明人 |
KUNNARI, TERO;BINDERNAGEL, HOLGER;WEISER, SASCHA;LUPTON, ANDREW;WALLERT, STEFAN |
分类号 |
C07H15/24 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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