发明名称 |
MATERIALS AND METHODS FOR THE DIFFERENTIAL DIAGNOSIS OF PANCREATIC LESIONS |
摘要 |
Levels of VEGF-A, VEGF-C and PGE2 were measured in patient groups presenting with different types of pancreatic lesions. Pancreatic fluids that exhibited high levels of VEGF-A and relative low levels of VEGF-C correlated well with a diagnosis of serous cystadenoma. Pancreatic fluids collected from cysts in patients that did not have a clinical diagnosis of pancreatic cancer and that exhibited relatively low levels of VEGF-A correlated with a diagnosis of intraductal papillary mucinous neoplasms (IPMN). Furthermore, the level of PGE2 increased with dysplastic stage. Contacting pancreatic fluid with reagents that selectively bind to VEGF-A, VEGF-C and PGE2 provide a useful diagnostic tool for identifying patients with these benign, pre-malignant or malignant lesions of the pancreas. |
申请公布号 |
WO2011031560(A2) |
申请公布日期 |
2011.03.17 |
申请号 |
WO2010US47017 |
申请日期 |
2010.08.27 |
申请人 |
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION;SCHMIDT, C., MAX;YIP-SCHNEIDER, MICHELE |
发明人 |
SCHMIDT, C., MAX;YIP-SCHNEIDER, MICHELE |
分类号 |
G01N33/574;G01N33/577 |
主分类号 |
G01N33/574 |
代理机构 |
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地址 |
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