<p>A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.</p>
申请公布号
WO2010035012(A9)
申请公布日期
2011.03.17
申请号
WO2009GB02310
申请日期
2009.09.25
申请人
UCB PHARMA S.A.;ADAMS, RALPH;HANCOCK, LAURA;HEYWOOD, SAM, PHILIP