发明名称 |
ADOPTIVE TRANSFER OF CD8+ T CELL CLONES DERIVED FROM CENTRAL MEMORY CELLS |
摘要 |
The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described. |
申请公布号 |
EP2099902(A4) |
申请公布日期 |
2011.03.16 |
申请号 |
EP20070852711 |
申请日期 |
2007.10.12 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
RIDDELL, STANLEY R.;BERGER, CAROLINA;JENSEN, MICHAEL C. |
分类号 |
A01N63/00;C12N5/0783 |
主分类号 |
A01N63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|